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Hans Knutsson . Photo

Hans Knutsson

Senior lecturer

Hans Knutsson . Photo

Constrained optimization of gradient waveforms for generalized diffusion encoding

Author

  • Jens Sjölund
  • Filip Szczepankiewicz
  • Markus Nilsson
  • Daniel Topgaard
  • Carl-Fredrik Westin
  • Hans Knutsson

Summary, in English

Diffusion MRI is a useful probe of tissue microstructure. The conventional diffusion encoding sequence, the single pulsed field gradient, has recently been challenged as more general gradient waveforms have been introduced. Out of these, we focus on q-space trajectory imaging, which generalizes the scalar b-value to a tensor valued entity. To take full advantage of its capabilities, it is imperative to respect the constraints imposed by the hardware, while at the same time maximizing the diffusion encoding strength. We provide a tool that achieves this by solving a constrained optimization problem that accommodates constraints on maximum gradient amplitude, slew rate, coil heating and positioning of radio frequency pulses. The method's efficacy and flexibility is demonstrated both experimentally and by comparison with previous work on optimization of isotropic diffusion sequences.

Department/s

  • Medical Radiation Physics, Lund
  • Multidimensional microstructure imaging
  • MR Physics
  • eSSENCE: The e-Science Collaboration
  • LTH Profile Area: Engineering Health
  • Diagnostic Radiology, (Lund)
  • Lund University Bioimaging Center
  • Physical Chemistry
  • Strategy

Publishing year

2015

Language

English

Pages

157-168

Publication/Series

Journal of Magnetic Resonance

Volume

261

Document type

Article

Publisher

Academic Press

Topic

  • Radiology and Medical Imaging

Status

Published

Research group

  • Multidimensional microstructure imaging
  • MR Physics

ISBN/ISSN/Other

  • ISSN: 1096-0856